Reflexology By Paula

Limbic Reflexology Research

The National Centre for Biotechnology Information (NCBI) has thousands of articles.

Understanding medical articles is not easy, but should you want to see evidence of the areas of the limbic brain that are involved with certain conditions and functions you can check out the links below. The articles are very detailed; I suggest you read only the abstract and conclusion.

Begin with.

The article above gives some of the limbic components after a brief history and mentions some functions and conditions: anxiety, depression, addiction, motivation, autonomic and endocrine responses, autism and aspergers, ADHD, biopolar, dementia, memory, sleep, fear and emotional responses.

Some limbic components (the entire list is not agreed upon):

  • Cingulate
  • Mamillary Body
  • Insula
  • Amygdala
  • Nucleus Accumbens
  • Pituitary
  • Subiculum
  • Rostral
  • Corpus Callosum
  • Habenula & Pineal
  • Hippocampus
  • Thalamus
  • Locus Coeruleus
  • Hypothalamus
  • Striatum
  • Substantia Nigra/VTA
  • Raphe
  • Periaqueductual Grey
  • Suprachiasmatic Nucleus

limbic BrainWanting to take your research further here are some interesting links; a small sample of what is available for some conditions (unable to list everything.) If you are not sure if limbic can help your condition please feel to email Paula –

Anorexia Nervosa

E Lawson 2013- Increase hypothalamic -Pituitary-Adrenal drive is associated with decrease appetite and hypoactivation of food motivation neurocircuitry in anorexia nervosa


Maletic 2007 – Neurobiology of Depression

Manoliu 2014 – Insula Dysfunction & Network switching

Lawson 2017 – Disrupted habenula function in major depression

Drevets 2009 – The subgenual Anterior Cingulate Cortex in Mood Disorders

Keller 2017 - HPA (Hypothalamus, Pituitary, Adrenal) Axis in major depression


Shiba 2016 – Beyond the Medial Regions of Prefrontal Cortex in the Regulation of Fear and Anxiety

Dan W Grupe 2013 – Uncertainty and Anticipation in Anxiety.

Lisa Shin 2010 – The neurocircuitry of Fear, Stress and Anxiety Disorders


Yvonne Lee 2011 – The role of the central nervous system in the generation and maintenance of chronic pain in rheumatoid arthritis, osteoarthritis and fibromyalgia.

Bellato 2012 – Fibromyalgia Syndrome: Etiology, Pathogenesis, Diagnosis and Treatment

Mira Meeus 2007 – Central Sensitization: a biopsychosocial explanation for chronic widespread pain in patients with fibromyalgia and chronic fatigue syndrome.

Chronic Pain

Mark A Lumley 2012 - Pain and Emotion: A Biopsychosocial Review of Recent Research 2012

Michael Ossipov 2010 Central Modulation of pain 2010

Peter D Drummond 2012

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